Guerilla Union, the live events company behind Rock The Bells and Paid Dues, announced this week the return of the annual Cypress Hill Smokeout 2010 on October 16 at the NOS Events Center in San Bernardino, CA.

The mind-opening music festival and cannabis expo made its celebrated return in 2009. Now, its back with its most eclectic and impressive line-up to date.

Making their only North-American appearance, Incubus is set to headline. Celebrated for his diverse and multi-genre blending musical style International musician Manu Chao makes his first US return since 2008. And additional performance highlights include Cypress Hill, Deadmau5 "unhooked", MGMT, Slightly Stoopid, Nas and Damian "Jr Gong" Marley, Atmosphere and more.

Cypress Hill's Smokeout is a platform that harnesses the power of music to celebrate self-expression, individuality and the freedom to choose one's own way of life. The festival will showcase over 20 acts on three stages.

"The Smoke Out is one of Guerilla Union's most successful live music artist partnerships and this year's show may be our most important and historic ever," said Chang Weisberg, Founder of Guerilla Union. "It represents our company's independent spirit and passion for creating unique live experiences. It's truly an honor to work with Cypress Hill and all of this year's world-class artists.

"SmokeOut is not only a well respected music festival, but also a platform for compassion, activism, and education for the entire medical marijuana community. With the help of Americans For Safe Access, Cypress Hill's SmokeOut will continue to support the legalization of Medical Marijuana and patient's rights. We need to encourage our community to vote this November. The timing of this year's show in October (Californians will be voting on tax and regulation this November) along with the incredible coalition of cannabis friendly artists, activists, and industry leaders joining this year’s bill will help raise awareness and support for important medical marijuana issues locally and nationally," Chang added.

Following their landmark performance of Black Sunday in its entirety at last year's event, Cypress Hill will make history again. The group will perform their ground-breaking, debut self-titled album for the first time in their career. The two-time platinum album was released in 1991, which included chart-topping singles, "Stoned Is The Way Of The Walk", "How I Could Just Kill A Man", "Latin Lingo" and "Hand On The Pump".

"Performing our self-titled album in its entirety is going to be a celebration and opportunity to treat our fans that have been supporting our music for nearly twenty years," said Cypress' B-Real. "We have a few more surprises to unveil as we prepare for SmokeOut and the upcoming vote in November. The SmokeOut exists to protect medical marijuana patient's rights and we encourage our fans to go to AmericansForSafeAccess.org to learn how they can make a difference. There are a lot of artists on this year's show that we love and respect. I can't wait to see all our fans, friends, and family back at the NOS Events Center in San Bernardino."

The full line-up is as follows: Icubus, Manu Chao, Deadmau5, MGMT, Cypress Hill, Slightly Stoopid, Nas & Damian Marley, Atmosphere, Living Colour, Living Legends, Iration, and Against The Girl.

Another major line-up announcement will be made this week, before on-sale.

The marijuana expo portion of the festival will host leading hemp industry exhibits featuring activists, cannabis education and legal workshops. An array of expert panel discussions, guest speakers and celebrity appearances will be featured thoughout the day. A 4:20 movie night will feature classic cannabis-themed films. Fans will also be treated to a Cypress Hill meet and greet, massive munchie gardens and a diverse lifestyle vendor village.

A complete program of activities and attractions will be announced at a later date.

Ticket pre-sale begin on Thursday (August 12) at 10:00 a.m. PST exclusively through Ticketfly.com; while tickets will go on-sale to the general public via Ticketfly.com on Saturday (August 14) at 10:00 a.m. PST.

For more info, visit SmokeoutFestival.com. Make sure to sign up for the newsletter to receive the latest information, festival updates and announcements.