Floyd Mayweather and Shane Mosley are set to begin USADA gold standard anti-doping program next Monday (March 22), as they continue to prepare for their forthcoming bout, dubbed "Who R U Picking?", set for Saturday, May 1st at the MGM Grand in Las Vegas.

It's the first time in history that athletes from any U.S. professional sport have reached out and demanded World Anti-Doing Code compliant drug testing.

Both Mayweather and Mosley are subjected to the testing program leading up to as well as after the fight.

"I am excited that Shane Mosley and I are willing to take these tests to ensure a fair fight on May 1," Mayweather said. "I just want to show the world that boxing is a clean sport and it is my hope that all fighters will take a similar stance and responsibility which reflects sportsmanship at the highest level and sets a new standard for safety in boxing."

"I think the testing program is a great idea and I did not hesitate for a minute about agreeing to it," added Mosley. "Let's hope that the rest of the boxing world follows Floyd's and my example."

Both fighters have agreed to the gold-standard, anti-doping program, the most stringent in sport, as outlined and mandated by USADA. It involves no-advance-notice sample collection of the athletes' blood and urine, prior to and after the fight, so that all banned substances, some of which do not show up in urine alone, are tested for thoroughly.

In a media conference call held on Thursday (March 18), one expert said both fighter's urine will even be frozen, stored and held for the coming years for additionally testing as new methods come available, a process done at the Olympic level.

The Mayweather/Mosley showdown takes place at the MGM Grand on May 1st. Tickets range from $150 all the way up to $1,250+. Get yours at Ticketmaster.com, or MGMGrand.com.

The fight will also broadcast live on HBO Pay-Per-View.